Opioid receptors: distinct roles in mood disorders.
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ABSTRACT:
SUBMITTER: Lutz PE
PROVIDER: S-EPMC3594542 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Opioid receptors: distinct roles in mood disorders.
Lutz Pierre-Eric PE Kieffer Brigitte L BL
Trends in neurosciences 20121206 3
The roles of opioid receptors in pain and addiction have been extensively studied, but their function in mood disorders has received less attention. Accumulating evidence from animal research reveals that mu, delta and kappa opioid receptors (MORs, DORs and KORs, respectively) exert highly distinct controls over mood-related processes. DOR agonists and KOR antagonists have promising antidepressant potential, whereas the risk-benefit ratio of currently available MOR agonists as antidepressants re ...[more]
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