Ontology highlight
ABSTRACT:
SUBMITTER: Korkaya H
PROVIDER: S-EPMC2602947 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Oncogene 20080630 47
The cancer stem cell hypothesis proposes that cancers arise in stem/progenitor cells through disregulation of self-renewal pathways generating tumors, which are driven by a component of 'tumor-initiating cells' retaining stem cell properties. The HER2 gene is amplified in 20-30% of human breast cancers and has been implicated in mammary tumorigenesis as well as in mediating aggressive tumor growth and metastasis. We demonstrate that HER2 overexpression drives mammary carcinogenesis, tumor growth ...[more]