Ontology highlight
ABSTRACT:
SUBMITTER: Zhou B
PROVIDER: S-EPMC5824875 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Zhou Beiyun B Flodby Per P Luo Jiao J Castillo Dan R DR Liu Yixin Y Yu Fa-Xing FX McConnell Alicia A Varghese Bino B Li Guanglei G Chimge Nyam-Osor NO Sunohara Mitsuhiro M Koss Michael N MN Elatre Wafaa W Conti Peter P Liebler Janice M JM Yang Chenchen C Marconett Crystal N CN Laird-Offringa Ite A IA Minoo Parviz P Guan Kunliang K Stripp Barry R BR Crandall Edward D ED Borok Zea Z
The Journal of clinical investigation 20180205 3
Claudins, the integral tight junction (TJ) proteins that regulate paracellular permeability and cell polarity, are frequently dysregulated in cancer; however, their role in neoplastic progression is unclear. Here, we demonstrated that knockout of Cldn18, a claudin family member highly expressed in lung alveolar epithelium, leads to lung enlargement, parenchymal expansion, increased abundance and proliferation of known distal lung progenitors, the alveolar epithelial type II (AT2) cells, activati ...[more]