Ontology highlight
ABSTRACT:
SUBMITTER: Lehmann A
PROVIDER: S-EPMC2603454 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Lehmann Andrea A Jechow Katharina K Enenkel Cordula C
EMBO reports 20081017 12
Blm10 is bound to the yeast proteasome core particle, a crucial protease of eukaryotic cells [corrected]. Two gates, at both ends of the CP, control the access of protein substrates to the catalytic cavity of the CP. Normally, substrate access is auto-inhibited by a closed gate conformation unless regulatory complexes are bound to the CP and translocate protein substrates in an ATP-dependent manner. Here, we provide evidence that Blm10 recognizes pre-activated open gate CPs, which are assumed to ...[more]