Ontology highlight
ABSTRACT:
SUBMITTER: Tian G
PROVIDER: S-EPMC3210322 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Tian Geng G Park Soyeon S Lee Min Jae MJ Huck Bettina B McAllister Fiona F Hill Christopher P CP Gygi Steven P SP Finley Daniel D
Nature structural & molecular biology 20111030 11
The Saccharomyces cerevisiae proteasome comprises a 19-subunit regulatory particle and a 28-subunit core particle. To be degraded, substrates must cross the core particle-regulatory particle interface, a site for complex conformational changes and regulatory events. This interface includes two aligned heteromeric rings, one formed by the six ATPase (Rpt) subunits of the regulatory particle and the other by the seven α subunits of the core particle. The Rpt C termini bind to intersubunit cavities ...[more]