Ontology highlight
ABSTRACT:
SUBMITTER: Posson DJ
PROVIDER: S-EPMC2603612 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Posson David J DJ Selvin Paul R PR
Neuron 20080701 1
Voltage-driven activation of Kv channels results from conformational changes of four voltage sensor domains (VSDs) that surround the K(+) selective pore domain. How the VSD helices rearrange during gating is an area of active research. Luminescence resonance energy transfer (LRET) is a powerful spectroscopic ruler uniquely suitable for addressing the conformational trajectory of these helices. Using a geometric analysis of numerous LRET measurements, we were able to estimate LRET probe positions ...[more]