Ontology highlight
ABSTRACT:
SUBMITTER: Gagnon DG
PROVIDER: S-EPMC2712970 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Gagnon Dominique G DG Bezanilla Francisco F
The Journal of general physiology 20090501 5
We sought to determine the contribution of an individual voltage sensor to Shaker's function. Concatenated heterotetramers of Shaker zH4 Delta(6-46) wild type (wt) in combination with a neutral S4 segment Shaker mutant (mut) with stoichiometries 2wt/2mut and 1wt/3mut were studied and compared with the 4wt concatenated homotetramer. A single charged voltage sensor is sufficient to open Shaker conductance with reduced delay (<1 ms) and at more hyperpolarized voltages compared with 4wt. In addition ...[more]