Ontology highlight
ABSTRACT:
SUBMITTER: Gu J
PROVIDER: S-EPMC2605155 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Gu Jiaping J Firestein Bonnie L BL Zheng James Q JQ
The Journal of neuroscience : the official journal of the Society for Neuroscience 20081101 46
It is generally believed that only the actin cytoskeleton resides in dendritic spines and controls spine morphology and plasticity. Here, we report that microtubules (MTs) are present in spines and that shRNA knockdown of the MT plus-end-binding protein EB3 significantly reduces spine formation. Furthermore, stabilization and inhibition of MTs by low doses of taxol and nocodazole enhance and impair spine formation elicited by BDNF (brain-derived neurotrophic factor), respectively. Therefore, MTs ...[more]