Ontology highlight
ABSTRACT:
SUBMITTER: Yoon S
PROVIDER: S-EPMC7007386 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Yoon Sehyoun S Parnell Euan E Kasherman Maria M Forrest Marc P MP Myczek Kristoffer K Premarathne Susitha S Sanchez Vega Michelle C MC Piper Michael M Burne Thomas H J THJ Jolly Lachlan A LA Wood Stephen A SA Penzes Peter P
Neuron 20191205 3
Variants in the ANK3 gene encoding ankyrin-G are associated with neurodevelopmental disorders, including intellectual disability, autism, schizophrenia, and bipolar disorder. However, no upstream regulators of ankyrin-G at synapses are known. Here, we show that ankyrin-G interacts with Usp9X, a neurodevelopmental-disorder-associated deubiquitinase (DUB). Usp9X phosphorylation enhances their interaction, decreases ankyrin-G polyubiquitination, and stabilizes ankyrin-G to maintain dendritic spine ...[more]