Ontology highlight
ABSTRACT:
SUBMITTER: Jin J
PROVIDER: S-EPMC2605283 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Jin Jie J Desai Bimal N BN Navarro Betsy B Donovan Adriana A Andrews Nancy C NC Clapham David E DE
Science (New York, N.Y.) 20081001 5902
The gene transient receptor potential-melastatin-like 7 (Trpm7) encodes a protein that functions as an ion channel and a kinase. TRPM7 has been proposed to be required for cellular Mg2+ homeostasis in vertebrates. Deletion of mouse Trpm7 revealed that it is essential for embryonic development. Tissue-specific deletion of Trpm7 in the T cell lineage disrupted thymopoiesis, which led to a developmental block of thymocytes at the double-negative stage and a progressive depletion of thymic medullary ...[more]