Ontology highlight
ABSTRACT:
SUBMITTER: Jin J
PROVIDER: S-EPMC3277139 | biostudies-other | 2012 Jan
REPOSITORIES: biostudies-other
Jin Jie J Wu Long-Jun LJ Jun Janice J Cheng Xiping X Xu Haoxing H Andrews Nancy C NC Clapham David E DE
Proceedings of the National Academy of Sciences of the United States of America 20111227 5
Global disruption of transient receptor potential-melastatin-like 7 (Trpm7) in mice results in embryonic lethality before embryonic day 7. Using tamoxifen-inducible disruption of Trpm7 and multiple Cre recombinase lines, we show that Trpm7 deletion before and during organogenesis results in severe tissue-specific developmental defects. We find that Trpm7 is essential for kidney development from metanephric mesenchyme but not ureteric bud. Disruption of neural crest Trpm7 at early stages results ...[more]