Metabolism of no-carrier-added 2-[18F]fluoro-L-tyrosine in rats.

ABSTRACT:

Background

Several fluorine-18 labelled fluoroamino acids have been evaluated as tracers for the quantitative assessment of cerebral protein synthesis in vivo by positron emission tomography (PET). Among these, 2-[18F]fluoro-L-tyrosine (2-[18F]Tyr) has been studied in mice at a low specific activity. Its incorporation into proteins is fast and metabolism via other pathways is limited. The present in vivo study was carried out in normal awake rats using no-carrier-added 2-[18F]Tyr. Under normal physiological conditions, we have studied the incorporation into proteins and the metabolism of the tracer in different brain areas.

Methods

No-carrier-added 2-[18F]Tyr was administered to awake rats equipped with chronic arterial and venous catheters. The time course of the plasma act

SUBMITTER: Aerts JJ 

PROVIDER: S-EPMC2606674 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature