Ontology highlight
ABSTRACT:
SUBMITTER: Anderson H
PROVIDER: S-EPMC4410717 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Anderson Harry H Pillarsetty Nagavarakishore N Cantorias Melchor M Lewis Jason S JS
Nuclear medicine and biology 20100306 4
An improved synthesis of 2'-[(18)F]-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodouracil ([(18)F]-FIAU) has been developed. The method utilizes trimethylsilyl trifluoromethanesulfonate (TMSOTf) catalyzed coupling of 2-deoxy-2-[(18)F]-fluoro-1,3,5-tri-O-benzoyl-d-arabinofuranose with 2,4-bis(trimethylsilyloxy)-5-iodouracil to yield the protected dibenzoyl-[(18)F]-FIAU. Dibenzoyl-[(18)F]-FIAU was deprotected with sodium methoxide to yield a mixture of alpha- and beta-anomers in a ratio of 1:1, w ...[more]