A functional MicroRNA-155 ortholog encoded by the oncogenic Marek's disease virus.
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ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC2612317 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Publications
A functional MicroRNA-155 ortholog encoded by the oncogenic Marek's disease virus.
Zhao Yuguang Y Yao Yongxiu Y Xu Hongtao H Lambeth Luke L Smith Lorraine P LP Kgosana Lydia L Wang Xiaowei X Nair Venugopal V
Journal of virology 20081022 1
Kaposi's sarcoma-associated herpesvirus-encoded microRNA (miRNA) MiR-K12-11 was recently shown to be a functional ortholog of miR-155, a miRNA that plays a major role in lymphoid malignancies and the modulation of immune responses. Here we show that miR-M4, encoded by the highly oncogenic Marek's disease virus of chickens, shares common targets with miR-155 and thus is also a functional ortholog of miR-155, the first one identified in an alphaherpesvirus. The observation that two distinct oncoge ...[more]
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