Ontology highlight
ABSTRACT:
SUBMITTER: Chang S
PROVIDER: S-EPMC3501198 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Nature medicine 20110925 10
BRCA1, a well-known tumor suppressor with multiple interacting partners, is predicted to have diverse biological functions. However, so far its only well-established role is in the repair of damaged DNA and cell cycle regulation. In this regard, the etiopathological study of low-penetrant variants of BRCA1 provides an opportunity to uncover its other physiologically important functions. Using this rationale, we studied the R1699Q variant of BRCA1, a potentially moderate-risk variant, and found t ...[more]