Conformational changes in the solution structure of the dengue virus 5' end in the presence and absence of the 3' untranslated region.
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ABSTRACT:
SUBMITTER: Polacek C
PROVIDER: S-EPMC2612390 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
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Conformational changes in the solution structure of the dengue virus 5' end in the presence and absence of the 3' untranslated region.
Polacek Charlotta C Foley Jonathan E JE Harris Eva E
Journal of virology 20081112 2
Dengue virus (DENV) is an approximately 10.7-kb positive-sense RNA virus that circularizes via RNA-RNA interactions between sequences in the 5' and 3' terminal regions. Complementarity between the cyclization sequence (CS) and the upstream AUG region (UAR) has been shown to be necessary for viral replication. Here, we present the solution structure of the 5' end of DENV type 2 in the presence and absence of the 3' end. We demonstrate that hybridization between the 5' and 3' CSs is independent of ...[more]
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