Ontology highlight
ABSTRACT:
SUBMITTER: Cudrici C
PROVIDER: S-EPMC2612730 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Journal of neuroimmunology 20081001 1
Complement activation plays a central role in autoimmune demyelination. To explore the possible effects of C5 on post-inflammatory tissue repair, we investigated the transcriptional profile induced by C5 in chronic experimental allergic encephalomyelitis (EAE) using oligonucleotide arrays. We used C5-deficient (C5-d) and C5-sufficient (C5-s) mice to compare the gene expression profile and we found that 390 genes were differentially regulated in C5-s mice as compared to C5-d mice during chronic E ...[more]