Ontology highlight
ABSTRACT:
SUBMITTER: Buckingham SC
PROVIDER: S-EPMC4285666 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Buckingham Susan C SC Ramos Theresa N TN Barnum Scott R SR
Epilepsia 20141110 12
Studies have demonstrated that the membrane attack complex (MAC) of complement can evoke seizures when injected directly into rodent brain. In the course of studies that examine the role of complement in the development of experimental cerebral malaria (ECM), we observed fewer seizures in mice deficient in C5, a component required for MAC formation. To determine if the MAC contributed to the tonic-clonic seizures characteristic of ECM, we performed long-term video-electroencephalography (EEG) on ...[more]