Quantitative analysis of human tissue-specific differences in methylation.
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ABSTRACT:
SUBMITTER: Igarashi J
PROVIDER: S-EPMC2613005 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Quantitative analysis of human tissue-specific differences in methylation.
Igarashi Jun J Muroi Satomi S Kawashima Hiroyuki H Wang Xiaofei X Shinojima Yui Y Kitamura Eiko E Oinuma Toshinori T Nemoto Norimichi N Song Fei F Ghosh Srimoyee S Held William A WA Nagase Hiroki H
Biochemical and biophysical research communications 20080919 4
Tissue-specific differentially methylated regions (tDMRs) have been identified and implicated for their indispensable involvement in mammalian development and tissue differentiation. In this report, a quantitative DNA methylation analysis was performed for 13 human orthologous regions of recently confirmed mouse tDMRs by using Sequenom Mass Array, by which bisulfite-treated fragments are quantitatively detected using time of flight mass spectroscopy analysis. Eight regions were shown as tDMRs in ...[more]
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