Measuring cell-type specific differential methylation in human brain tissue.
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ABSTRACT:
SUBMITTER: Montano CM
PROVIDER: S-EPMC4054676 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Measuring cell-type specific differential methylation in human brain tissue.
Montaño Carolina M CM Irizarry Rafael A RA Kaufmann Walter E WE Talbot Konrad K Gur Raquel E RE Feinberg Andrew P AP Taub Margaret A MA
Genome biology 20130830 8
The behavior of epigenetic mechanisms in the brain is obscured by tissue heterogeneity and disease-related histological changes. Not accounting for these confounders leads to biased results. We develop a statistical methodology that estimates and adjusts for celltype composition by decomposing neuronal and non-neuronal differential signal. This method provides a conceptual framework for deconvolving heterogeneous epigenetic data from postmortem brain studies. We apply it to find cell-specific di ...[more]
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