Ontology highlight
ABSTRACT:
SUBMITTER: Menezes GC
PROVIDER: S-EPMC2613341 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Menezes Gustavo C GC Miron-Mendoza Miguel M Ho Chin-Han CH Jiang Hongmei H Grinnell Frederick F
Experimental cell research 20080726 16
Tractional force exerted by tissue cells in 3D collagen matrices can be utilized for matrix remodeling or cell migration. The interrelationship between these motile processes is not well understood. The current studies were carried out to test the consequences of oncogenic Ras (H-Ras(V12)) transformation on human fibroblast contraction and migration in 3D collagen matrices. Beginning with hTERT-immortalized cells, we prepared fibroblasts stably transformed with E6/E7 and with the combination HPV ...[more]