Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Cadahia B
PROVIDER: S-EPMC3013000 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Pérez-Cadahía Beatriz B Drobic Bojan B Espino Paula S PS He Shihua S Mandal Soma S Healy Shannon S Davie James R JR
The Journal of biological chemistry 20101110 1
Activated by the RAS-MAPK signaling pathway, MSK1 is recruited to immediate-early gene (IEG) regulatory regions, where it phosphorylates histone H3 at Ser-10 or Ser-28. Chromatin remodelers and modifiers are then recruited by 14-3-3 proteins, readers of phosphoserine marks, leading to the occupancy of IEG promoters by the initiation-engaged form of RNA polymerase II and the onset of transcription. In this study, we show that this mechanism of IEG induction, initially elucidated in parental 10T1/ ...[more]