Ontology highlight
ABSTRACT:
SUBMITTER: Townsend PD
PROVIDER: S-EPMC2613629 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Townsend Philip D PD Holliday Phillip M PM Fenyk Stepan S Hess Kenneth C KC Gray Michael A MA Hodgson David R W DR Cann Martin J MJ
The Journal of biological chemistry 20081113 2
Carbon dioxide is fundamental to the physiology of all organisms. There is considerable interest in the precise molecular mechanisms that organisms use to directly sense CO(2). Here we demonstrate that a mammalian recombinant G-protein-activated adenylyl cyclase and the related Rv1625c adenylyl cyclase of Mycobacterium tuberculosis are specifically stimulated by CO(2). Stimulation occurred at physiological concentrations of CO(2) through increased k(cat). CO(2) increased the affinity of enzyme f ...[more]