Ontology highlight
ABSTRACT:
SUBMITTER: Guo X
PROVIDER: S-EPMC2613769 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Guo Xun X Gourronc Francoise F Audic Yann Y Lyons-Levy Gillian G Mitchell Therese T Hartley Rebecca S RS
Biochemical and biophysical research communications 20081016 2
In Xenopus embryos, maternal cyclins drive the first 12 cell divisions after which several cyclins are terminally degraded, including cyclin B2. Cyclin B2 disappearance is due to transcription-mediated mRNA deadenylation at the midblastula transition, when transcription initiates and the cell cycle lengthens. To further define the mechanism, we characterized proteins capable of binding cyclin B2 3'UTR. We show that ElrA and AUF1 compete for binding to regions containing cytoplasmic polyadenylati ...[more]