Ontology highlight
ABSTRACT:
SUBMITTER: Audic Y
PROVIDER: S-EPMC86712 | biostudies-literature | 2001 Mar
REPOSITORIES: biostudies-literature
Audic Y Y Anderson C C Bhatty R R Hartley R S RS
Molecular and cellular biology 20010301 5
At the midblastula transition, the Xenopus laevis embryonic cell cycle is remodeled from rapid alternations between S and M phases to become the complex adult cell cycle. Cell cycle remodeling occurs after zygotic transcription initiates and is accompanied by terminal downregulation of maternal cyclins A1 and B2. We report here that the disappearance of both cyclin A1 and B2 proteins is preceded by the rapid deadenylation of their mRNAs. A specific mechanism triggers this deadenylation. This mec ...[more]