Ontology highlight
ABSTRACT:
SUBMITTER: Doi K
PROVIDER: S-EPMC2614371 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Kidney international 20080716 8
While it is known that risk of death from sepsis is higher in patients with pre-existing chronic kidney disease its mechanism is unknown. To study this we established a two-stage mouse model where renal disease was first induced by folic acid injection followed by sub-lethal cecal ligation and puncture to induce sepsis. Septic mice with pre-existing renal disease had significantly higher mortality, serum creatinine, vascular permeability, plasma vascular endothelial growth factor (VEGF) levels, ...[more]