Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells.
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ABSTRACT:
SUBMITTER: Bosque A
PROVIDER: S-EPMC2614643 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
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Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells.
Bosque Alberto A Planelles Vicente V
Blood 20081010 1
The use of antiretroviral therapy in HIV type 1 (HIV-1)-infected patients does not lead to virus eradication. This is due, to a significant degree, to the fact that HIV-1 can establish a highly stable reservoir of latently infected cells. In this work, we describe an ex vivo experimental system that generates high levels of HIV-1 latently infected memory cells using primary CD4+ T cells. Using this model, we were able to dissect the T cell-signaling pathways and to characterize the long terminal ...[more]
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