Ontology highlight
ABSTRACT:
SUBMITTER: Novis CL
PROVIDER: S-EPMC3826617 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Novis Camille L CL Archin Nancie M NM Buzon Maria J MJ Verdin Eric E Round June L JL Lichterfeld Mathias M Margolis David M DM Planelles Vicente V Bosque Alberto A
Retrovirology 20131024
<h4>Background</h4>Toll-like receptors (TLRs) are crucial for recognition of pathogen-associated molecular patterns by cells of the innate immune system. TLRs are present and functional in CD4⁺ T cells. Memory CD4⁺ T cells, predominantly central memory cells (TCM), constitute the main reservoir of latent HIV-1. However, how TLR ligands affect the quiescence of latent HIV within central memory CD4⁺ T cells has not been studied.<h4>Results</h4>We evaluated the ability of a broad panel of TLR agoni ...[more]