Ontology highlight
ABSTRACT:
SUBMITTER: Karl MO
PROVIDER: S-EPMC2614791 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Karl Mike O MO Hayes Susan S Nelson Branden R BR Tan Kristine K Buckingham Brian B Reh Thomas A TA
Proceedings of the National Academy of Sciences of the United States of America 20081125 49
Müller glia can serve as a source of new neurons after retinal damage in both fish and birds. Investigations of regeneration in the mammalian retina in vitro have provided some evidence that Müller glia can proliferate after retinal damage and generate new rods; however, the evidence that this occurs in vivo is not conclusive. We have investigated whether Müller glia have the potential to generate neurons in the mouse retina in vivo by eliminating ganglion and amacrine cells with intraocular NMD ...[more]