Ontology highlight
ABSTRACT:
SUBMITTER: Ooto S
PROVIDER: S-EPMC518808 | biostudies-other | 2004 Sep
REPOSITORIES: biostudies-other
Ooto Sotaro S Akagi Tadamichi T Kageyama Ryoichiro R Akita Joe J Mandai Michiko M Honda Yoshihito Y Takahashi Masayo M
Proceedings of the National Academy of Sciences of the United States of America 20040907 37
It has long been believed that the retina of mature mammals is incapable of regeneration. In this study, using the N-methyl-D-aspartate neurotoxicity model of adult rat retina, we observed that some Müller glial cells were stimulated to proliferate in response to a toxic injury and produce bipolar cells and rod photoreceptors. Although these newly produced neurons were limited in number, retinoic acid treatment promoted the number of regenerated bipolar cells. Moreover, misexpression of basic he ...[more]