Ontology highlight
ABSTRACT:
SUBMITTER: Jeansson M
PROVIDER: S-EPMC2615716 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Jeansson Marie M Björck Karin K Tenstad Olav O Haraldsson Börje B
Journal of the American Society of Nephrology : JASN 20081210 1
The pathophysiology underlying the nephrotic syndrome is becoming clear for several inherited podocytopathies; the mechanisms of injury that lead to the acquired forms of this disease are not well understood. We explored these mechanisms using the mouse model of adriamycin-induced proteinuria.We estimated the fractional clearances for FITC-Ficolls, albumin, and neutral albumin in cooled, isolated,perfused kidneys (cIPK) in situ. Treatment with adriamycin led to a significant increase in the frac ...[more]