Altered gut microbiome promotes proteinuria in mice induced by Adriamycin.
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ABSTRACT:
SUBMITTER: Jiang Q
PROVIDER: S-EPMC5833890 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Altered gut microbiome promotes proteinuria in mice induced by Adriamycin.
Jiang Qian Q He Xiwei X Zou Yuntao Y Ding Yin Y Li Huang H Chen Huimei H
AMB Express 20180228 1
Inflammation has recently been attributed to dysbiosis of the gut microbiome, which has been linked to proteinuria in chronic kidney disease. Since Adriamycin<sup>®</sup> (ADR) is widely used to induce proteinuria in mouse models, the aim of this study was to explore the potential effect of gut microbiome on this process. Both ADR resistant (C57BL/6) and susceptible (BALB/C) strains were part of the induced nephropathy with ADR injection. BALB/C mice significantly presented increased urinary alb ...[more]
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