Ontology highlight
ABSTRACT:
SUBMITTER: Macconi D
PROVIDER: S-EPMC2615725 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Macconi Daniela D Chiabrando Chiara C Schiarea Silvia S Aiello Sistiana S Cassis Linda L Gagliardini Elena E Noris Marina M Buelli Simona S Zoja Carla C Corna Daniela D Mele Caterina C Fanelli Roberto R Remuzzi Giuseppe G Benigni Ariela A
Journal of the American Society of Nephrology : JASN 20081217 1
The role of dendritic cells (DC) that accumulate in the renal parenchyma of non-immune-mediated proteinuric nephropathies is not well understood. Under certain circumstances, DC capture immunologically ignored antigens, including self-antigens, and present them within MHC class I, initiating an autoimmune response. We studied whether DC could generate antigenic peptides from the self-protein albumin. Exposure of rat proximal tubular cells to autologous albumin resulted in its proteolytic cleavag ...[more]