Cutting antigenic peptides down to size.
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ABSTRACT:
SUBMITTER: Natarajan K
PROVIDER: S-EPMC6901298 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Cutting antigenic peptides down to size.
Natarajan Kannan K Margulies David H DH
The Journal of biological chemistry 20191201 49
A critical step in antigen presentation is the degradative processing of peptides by aminopeptidases in the endoplasmic reticulum. It is unclear whether these enzymes act only on free peptides or on those bound to their major histocompatibility complex (MHC)-I-presenting molecules. A recent study examined the structure and biophysics of N-terminally extended peptides in complex with MHC-I, revealing the conformational adjustment of MHC to permit both binding of the peptide core and exposure of t ...[more]
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