Ontology highlight
ABSTRACT:
SUBMITTER: Tycowski KT
PROVIDER: S-EPMC26158 | biostudies-literature | 1996 Dec
REPOSITORIES: biostudies-literature
Tycowski K T KT Smith C M CM Shu M D MD Steitz J A JA
Proceedings of the National Academy of Sciences of the United States of America 19961201 25
Vertebrate cells contain a large number of small nucleolar RNA (snoRNA) species, the vast majority of which bind fibrillarin. Most of the fibrillarin-associated snoRNAs can form 10- to 21-nt duplexes with rRNA and are thought to guide 2'-O-methylation of selected nucleotides in rRNA. These include mammalian UHG (U22 host gene)-encoded U25-U31 snoRNAs. We have characterized two novel human snoRNA species, U62 and U63, which similarly exhibit 15- (with one interruption) and 12-nt complementarities ...[more]