In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor.
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ABSTRACT:
SUBMITTER: Rappu P
PROVIDER: S-EPMC262106 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Publications
In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor.
Rappu Pekka P Pullinen Terhi T Mäntsälä Pekka P
Journal of bacteriology 20031101 22
The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA. PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP binding motif of PurR caused strong repression regardless of purine exclusions or additions, establishing the role of PRPP as regulator of PurR. ...[more]
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