Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC2626729 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Li Weimin W Kotoshiba Shuhei S Berthet Cyril C Hilton Mary Beth MB Kaldis Philipp P
Proceedings of the National Academy of Sciences of the United States of America 20090107 2
The G(1)/S-phase transition is a well-toned switch in the mammalian cell cycle. Cdk2, Cdk4, and the rate-limiting tumor suppressor retinoblastoma protein (Rb) have been studied in separate animal models, but interactions between the kinases and Rb in vivo have yet to be investigated. To further dissect the regulation of the G(1) to S-phase progression, we generated Cdk2(-/-)Cdk4(-/-)Rb(-/-) (TKO) mutant mice. TKO mice died at midgestation with major defects in the circulatory systems and display ...[more]