Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC5342150 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Yang Hao H Zhao Xiaoping X Zhao Li L Liu Liu L Li Jiajin J Jia Wenzhi W Liu Jianjun J Huang Gang G
Oncotarget 20161101 44
Although cancer cells are known to be "addicted" to glucose, the effect of glucose in proliferation of these cells remains elusive. Here, we report that upon glucose induction, protein arginine methyltransferase 5 (PRMT5) exerts a profound effect on the G1-S cell cycle progression via directly interacting with cyclin dependent kinase 4 (CDK4) in hepatocellular carcinoma (HCC). Upregulation of both PRMT5 and CDK4 predicts more malignant characteristics in human HCC tissues. Mechanistically, gluco ...[more]