Ontology highlight
ABSTRACT:
SUBMITTER: Peterlin Z
PROVIDER: S-EPMC2628580 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Peterlin Zita Z Li Yadi Y Sun Guangxing G Shah Rohan R Firestein Stuart S Ryan Kevin K
Chemistry & biology 20081201 12
Olfactory receptors (ORs) form a large family of G protein-coupled receptor proteins (GPCRs) responsible for sensing the ambient chemical environment. The molecular recognition strategies used by ORs to detect and distinguish odorant molecules are unclear. Here, we investigated the variable of odorant carbon chain conformation for an established odorant-OR pair: n-octanal and rat OR-I7. A series of conformationally restricted octanal mimics were tested on live olfactory sensory neurons (OSNs). O ...[more]