Ontology highlight
ABSTRACT:
SUBMITTER: Ferreira T
PROVIDER: S-EPMC4412037 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Ferreira Todd T Wilson Sarah R SR Choi Yoon Gi YG Risso Davide D Dudoit Sandrine S Speed Terence P TP Ngai John J
Neuron 20140201 4
Olfactory sensory neurons express just one out of a possible ∼ 1,000 odorant receptor genes, reflecting an exquisite mode of gene regulation. In one model, once an odorant receptor is chosen for expression, other receptor genes are suppressed by a negative feedback mechanism, ensuring a stable functional identity of the sensory neuron for the lifetime of the cell. The signal transduction mechanism subserving odorant receptor gene silencing remains obscure, however. Here, we demonstrate in the ze ...[more]