Unknown

Dataset Information

0

Silencing of odorant receptor genes by G protein ?? signaling ensures the expression of one odorant receptor per olfactory sensory neuron.


ABSTRACT: Olfactory sensory neurons express just one out of a possible ? 1,000 odorant receptor genes, reflecting an exquisite mode of gene regulation. In one model, once an odorant receptor is chosen for expression, other receptor genes are suppressed by a negative feedback mechanism, ensuring a stable functional identity of the sensory neuron for the lifetime of the cell. The signal transduction mechanism subserving odorant receptor gene silencing remains obscure, however. Here, we demonstrate in the zebrafish that odorant receptor gene silencing is dependent on receptor activity. Moreover, we show that signaling through G protein ?? subunits is both necessary and sufficient to suppress the expression of odorant receptor genes and likely acts through histone methylation to maintain the silenced odorant receptor genes in transcriptionally inactive heterochromatin. These results link receptor activity with the epigenetic mechanisms responsible for ensuring the expression of one odorant receptor per olfactory sensory neuron.

SUBMITTER: Ferreira T 

PROVIDER: S-EPMC4412037 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Silencing of odorant receptor genes by G protein βγ signaling ensures the expression of one odorant receptor per olfactory sensory neuron.

Ferreira Todd T   Wilson Sarah R SR   Choi Yoon Gi YG   Risso Davide D   Dudoit Sandrine S   Speed Terence P TP   Ngai John J  

Neuron 20140201 4


Olfactory sensory neurons express just one out of a possible ∼ 1,000 odorant receptor genes, reflecting an exquisite mode of gene regulation. In one model, once an odorant receptor is chosen for expression, other receptor genes are suppressed by a negative feedback mechanism, ensuring a stable functional identity of the sensory neuron for the lifetime of the cell. The signal transduction mechanism subserving odorant receptor gene silencing remains obscure, however. Here, we demonstrate in the ze  ...[more]

Similar Datasets

2013-12-16 | GSE53334 | GEO
2013-12-16 | E-GEOD-53334 | biostudies-arrayexpress
| S-EPMC1994056 | biostudies-literature
| S-EPMC4356613 | biostudies-literature
| S-EPMC4426395 | biostudies-literature
| S-EPMC8043390 | biostudies-literature
| S-EPMC6756926 | biostudies-literature
| S-EPMC5086798 | biostudies-literature
| S-EPMC4492312 | biostudies-literature
2016-11-21 | GSE74527 | GEO