Ontology highlight
ABSTRACT:
SUBMITTER: Wong DJ
PROVIDER: S-EPMC2628721 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Wong David J DJ Liu Helen H Ridky Todd W TW Cassarino David D Segal Eran E Chang Howard Y HY
Cell stem cell 20080401 4
Self-renewal is a hallmark of stem cells and cancer, but existence of a shared stemness program remains controversial. Here, we construct a gene module map to systematically relate transcriptional programs in embryonic stem cells (ESCs), adult tissue stem cells, and human cancers. This map reveals two predominant gene modules that distinguish ESCs and adult tissue stem cells. The ESC-like transcriptional program is activated in diverse human epithelial cancers and strongly predicts metastasis an ...[more]