Ontology highlight
ABSTRACT:
SUBMITTER: Strnad P
PROVIDER: S-EPMC2628752 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Strnad Petr P Leidel Sebastian S Vinogradova Tatiana T Euteneuer Ursula U Khodjakov Alexey A Gönczy Pierre P
Developmental cell 20070801 2
Centrosome duplication involves the formation of a single procentriole next to each centriole, once per cell cycle. The mechanisms governing procentriole formation and those restricting its occurrence to one event per centriole are poorly understood. Here, we show that HsSAS-6 is necessary for procentriole formation and that it localizes asymmetrically next to the centriole at the onset of procentriole formation. HsSAS-6 levels oscillate during the cell cycle, with the protein being degraded in ...[more]