Ontology highlight
ABSTRACT:
SUBMITTER: Izquierdo D
PROVIDER: S-EPMC4152953 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Izquierdo Denisse D Wang Won-Jing WJ Uryu Kunihiro K Tsou Meng-Fu Bryan MF
Cell reports 20140814 4
Vertebrate centrioles lose their geometric scaffold, the cartwheel, during mitosis, concurrently with gaining the ability to recruit the pericentriolar material (PCM) and thereby function as the centrosome. Cartwheel removal has recently been implicated in centriole duplication, but whether "cartwheel-less" centrioles are intrinsically stable or must be maintained through other modifications remains unclear. Here, we identify a newborn centriole-enriched protein, KIAA1731/CEP295, specifically me ...[more]