Ontology highlight
ABSTRACT:
SUBMITTER: Backlund MG
PROVIDER: S-EPMC2628771 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Backlund Michael G MG Mann Jason R JR Holla Vijaykumar R VR Shi Qiong Q Daikoku Takikoku T Dey Sudhansu K SK DuBois Raymond N RN
Cancer research 20081101 22
Prostaglandin E(2) (PGE(2)) promotes cancer progression by modulating proliferation, apoptosis, angiogenesis, and the immune response. Enzymatic degradation of PGE(2) involves the NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Recent reports have shown a marked diminution of 15-PGDH expression in colorectal carcinomas (CRC). We report here that treatment of CRC cells with histone deacetylase (HDAC) inhibitors, including sodium butyrate and valproic acid, induces 15-PGDH expres ...[more]