Ontology highlight
ABSTRACT:
SUBMITTER: Wright KJ
PROVIDER: S-EPMC2629200 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Wright Kevin J KJ Tjian Robert R
Proceedings of the National Academy of Sciences of the United States of America 20081230 1
Understanding the diverse activities of the multisubunit core promoter recognition complex TFIID in vivo requires knowledge of how individual subunits contribute to overall functions of this TATA box-binding protein (TBP)/TBP-associated factor (TAF) complex. By generating altered holo-TFIID complexes in Drosophila we identify the ETO domain of TAF4 as a coactivator domain likely targeted by Pygopus, a protein that is required for Wingless-induced transcription of naked cuticle. These results est ...[more]