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Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo.


ABSTRACT: Understanding the diverse activities of the multisubunit core promoter recognition complex TFIID in vivo requires knowledge of how individual subunits contribute to overall functions of this TATA box-binding protein (TBP)/TBP-associated factor (TAF) complex. By generating altered holo-TFIID complexes in Drosophila we identify the ETO domain of TAF4 as a coactivator domain likely targeted by Pygopus, a protein that is required for Wingless-induced transcription of naked cuticle. These results establish a coactivator function of TAF4 and provide a strategy to dissect mechanisms of TFIID function in vivo.

SUBMITTER: Wright KJ 

PROVIDER: S-EPMC2629200 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

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Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo.

Wright Kevin J KJ   Tjian Robert R  

Proceedings of the National Academy of Sciences of the United States of America 20081230 1


Understanding the diverse activities of the multisubunit core promoter recognition complex TFIID in vivo requires knowledge of how individual subunits contribute to overall functions of this TATA box-binding protein (TBP)/TBP-associated factor (TAF) complex. By generating altered holo-TFIID complexes in Drosophila we identify the ETO domain of TAF4 as a coactivator domain likely targeted by Pygopus, a protein that is required for Wingless-induced transcription of naked cuticle. These results est  ...[more]

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