Ontology highlight
ABSTRACT:
SUBMITTER: Langer D
PROVIDER: S-EPMC4820908 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Nature communications 20160330
TAF4 (TATA-binding protein-associated factor 4) and its paralogue TAF4b are components of the TFIID core module. We inactivated the murine Taf4a gene to address Taf4 function during embryogenesis. Here we show that Taf4a(-/-) embryos survive until E9.5 where primary germ layers and many embryonic structures are identified showing Taf4 is dispensable for their specification. In contrast, Taf4 is required for correct patterning of the trunk and anterior structures, ventral morphogenesis and proper ...[more]