Ontology highlight
ABSTRACT:
SUBMITTER: Andretic R
PROVIDER: S-EPMC2629270 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Andretic Rozi R Kim Young-Cho YC Jones Frederick S FS Han Kyung-An KA Greenspan Ralph J RJ
Proceedings of the National Academy of Sciences of the United States of America 20081211 51
The arousing and motor-activating effects of psychostimulants are mediated by multiple systems. In Drosophila, dopaminergic transmission is involved in mediating the arousing effects of methamphetamine, although the neuronal mechanisms of caffeine (CAFF)-induced wakefulness remain unexplored. Here, we show that in Drosophila, as in mammals, the wake-promoting effect of CAFF involves both the adenosinergic and dopaminergic systems. By measuring behavioral responses in mutant and transgenic flies ...[more]