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Calmodulin inhibitory activity of the malbrancheamides and various analogs.

ABSTRACT: The preparation and biological activity of various structural analogs of the malbrancheamides are disclosed. The impact of indole chlorination, C-12a relative stereochemistry, and bicyclo[2.2.2]diazaoctane core oxidation state on the ability of these analogs to inhibit calmodulin dependent phosphodiesterase (PDE1) was studied, and a number of potent compounds were identified.

SUBMITTER: Miller KA

PROVIDER: S-EPMC2629606 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature

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Calmodulin inhibitory activity of the malbrancheamides and various analogs.

Miller Kenneth A KA Figueroa Mario M Valente Meriah W N MW Greshock Thomas J TJ Mata Rachel R Williams Robert M RM

Bioorganic & medicinal chemistry letters 20081017 24

The preparation and biological activity of various structural analogs of the malbrancheamides are disclosed. The impact of indole chlorination, C-12a relative stereochemistry, and bicyclo[2.2.2]diazaoctane core oxidation state on the ability of these analogs to inhibit calmodulin dependent phosphodiesterase (PDE1) was studied, and a number of potent compounds were identified. ...[more]

PMID: 18986806

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