Association between haplotypes of manganese superoxide dismutase (SOD2), smoking, and lung cancer risk.
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ABSTRACT:
SUBMITTER: Gallagher CJ
PROVIDER: S-EPMC2630476 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
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Association between haplotypes of manganese superoxide dismutase (SOD2), smoking, and lung cancer risk.
Gallagher Carla J CJ Ahn Kwangmi K Knipe Ashley L AL Dyer Anne-Marie AM Richie John P JP Lazarus Philip P Muscat Joshua E JE
Free radical biology & medicine 20080927 1
Tobacco smoke contains high concentrations of reactive oxygen species (ROS) that can damage DNA, proteins, and lipids. Manganese superoxide dismutase (SOD2) catalyzes the dismutation of superoxide radicals into hydrogen peroxide and protects against oxidative stress in lung tissues. Three tagSNPs were identified in one block of high linkage disequilibrium that spans the entire SOD2 gene and 5-kb promoter region. These tagSNPs, representing four haplotypes (TAA, TCA, TCG, CCG), were genotyped in ...[more]
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