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Photoactive barbiturate receptors: an ultimate lock-and-key system in which the key unlocks the lock.

ABSTRACT: Conditional photofragmentation is achieved with binary systems incorporating the isophthaloyl bis-aminopyridine barbiturate recognition motif and dithiane- or trithiane-based photolabile modules, which cleave only in the presence of an external sensitizer. The components of the host-guest molecular recognition pair were each outfitted with either the sensitizer or the photocleavable module. In these pairs, photoinduced fragmentation is contingent on a molecular recognition event, which brings the sensitizer into the immediate proximity of the photolabile latch. [structure: see text]

SUBMITTER: Lakkakula S

PROVIDER: S-EPMC2631392 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

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Photoactive barbiturate receptors: an ultimate lock-and-key system in which the key unlocks the lock.

Lakkakula Suman S Mitkin Oleg D OD Valiulin Roman A RA Kutateladze Andrei G AG

Organic letters 20070210 6

Conditional photofragmentation is achieved with binary systems incorporating the isophthaloyl bis-aminopyridine barbiturate recognition motif and dithiane- or trithiane-based photolabile modules, which cleave only in the presence of an external sensitizer. The components of the host-guest molecular recognition pair were each outfitted with either the sensitizer or the photocleavable module. In these pairs, photoinduced fragmentation is contingent on a molecular recognition event, which brings th ...[more]

PMID: 17291004

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